The endocannabinoid system is populated by millions of specialized cellular receptors that bind perfectly with both endocannabinoids (such as anandamide and 2-AG) and the phytocannabinoids from cannabis, such as CBG and CBD. Two primary variants of ECS receptors have been discovered, CB1 and CB2.

The widespread distribution of cannabinoid receptors [CB1 and CB2] regulate a variety of central and peripheral physiological functions, including neuronal development, neuromodulatory processes, [and] energy metabolism,” reported a 2014 research study. The research also found that CB1 and CB2 receptors are involved in “cardiovascular, respiratory, [and] reproductive functions.”

CB1

CB1 is found in greatest density in the brain and central nervous system (CNS), but present throughout the body in lower numbers.

CB2

CB2 receptors are found mostly in the tissues, glands, and organs of the immune system. CB2 receptors have been found in the brain and CNS, but are vastly outnumbered by their CB1 peers.

CB1

CB1 is found in greatest density in the brain and central nervous system (CNS), but present throughout the body in lower numbers.

CBG

According to a 2018 research study, CBG binds with both CB1 and CB2 receptors. This gives CBG greater potential efficacy than cannabinoids that bind with only a single type of receptor, such as CB2. Reported the study’s authors, ”The results indicate that CBG is indeed effective as regulator of endocannabinoid signaling.”

CB2

CB2 receptors are found mostly in the tissues, glands, and organs of the immune system. CB2 receptors have been found in the brain and CNS, but are vastly outnumbered by their CB1 peers.